Possible Interaction: Ferrous and Vitamin C

“Under normoxia, a sharp decline in cardiac parameters was observed following co-perfusion of low (20 μM) and high (100 μM) ascorbic acid (Asc) with ferrous Hb.”

“ Ascorbic acid , known to potentiate the pro-oxidant properties of iron, was also capable of markedly stabilizing ferrous ions.”

“The results showed that PA, SS or SO decreases iron uptake from ferrous Fe, and AA can counteract their inhibiting effect on ferrous iron absorption and thus increase ferrous iron uptake.”

“It is believed that vitamin C can reduce both ferric (Fe3+) and ferrous (Fe2+) ions, and also facilitate the accessibility of iron to chelators through increase of iron release from the reticuloendothelial system.”

“TET dioxygenases require 2-oxoglutarate, oxygen and Fe(II ) for their activity, which is enhanced in the presence of ascorbic acid.”

“ Ascorbic acid in the intestinal lumen trebled the absorption even of ferrous iron.”

“These results suggest that ascorbic acid in the presence of contaminant ferrous ions induced a decrease in functional DA transporters, probably through a lipid peroxidation process involving oxidation of sulfhydryl groups and at least in part through a decrease of Na+/K+ ATPase activity.”

“Rapid dissociated Fe(III)-ascorbic acid complexes are formed after the mixing of Fe(II) (100 mkM) with ascorbic acid (1 mM) at pH-7,4.”

“It was demonstrated that ascorbic acid had a very obvious inhibitory effect on the oxidation of ferrous iron and could maintain the stability of ferrous iron in solid and solution for a long time, thus improving the bioavailability of iron.”

“In this study, we demonstrate that ascorbic acid (AA) could enhance ROS generation via oxygen activation by ferrous irons (AA/Fe(II)/air) and thus improve the degradation of rhodamine (RhB) significantly.”