Possible Interaction: Ferrous Sulfate and Iron, Dietary

“The absorption of 50 mg of iron as ferrous sulfate increased 2.4-fold from 3.8% to 9.4% (P < .05) when given without food and 4.2-fold from 1.4% to 5.9% (P < .05) when given with food after erythropoietin administration.”

“This work, however, has been justifiably criticized because there was no control group, and because the absorption of iron from the added ferrous sulphate would have to have been in excess of 30% in order to account for the recorded Hb rise during the first two months of supplementation.”

“These values were significantly lower than absorption from the same dose of iron given as ferrous sulphate , which averaged 24.1% without and 8.2% with food.”

“ Ferrous sulfate supplementation significantly increased risk of GI side-effects versus placebo with an odds ratio (OR) … [95% CI 1.74–3.08, p<0.0001, I2 = 53.6%] and versus IV iron with an OR of 3.05 [95% CI …-4.48, p<0.0001, I2 = 41.6%].”

“ Ferrous sulfate plus vitamin C added to human milk and formulas fortified with iron increased oxidative stress.”

“The absorption of 50 mg iron as ferrous sulfate increased from 2.0% to 17.9% when given with food (p < 0.001) and from 7.0% to 24.6% when given with water (p < 0.001).”

“1,2 In the present case, an overdose of ferrous sulfate , taken in an apparent suicidal gesture, resulted in a moderately severe toxic reaction to iron.”

“However, the addition of iron sulfate acidified the soil, decreased soil pore water As concentrations, and increased the ones of Fe and Pb.”

“In vitro exposure to iron significantly enhanced lipid peroxidation in hepatic homogenates from untreated, melatonin-treated, or E2-injected hamsters; in the hepatic homogenates of hamsters given both E2 and melatonin, ferrous sulfate failed to augment lipid peroxidation.”

“The optical spectra of BT were modified in the presence of ferrous sulphate , revealing a new absorption peak at 259 nm indicating complexation with iron.”