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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Ferrous
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“The determination of several parameters (iron, calcium, magnesium, alpha-hydroxyproline, lipid peroxidation, hepatomegalic and splenomegalic indexes) showed that ferrous and ferric lactates provoke an increase of calcium in the liver, higher than that of ethanol in the control animals.”
Iron-ethanol synergism and pathological liver transformation.“ Calcium increased ferrous iron uptake and overcame the effects of metabolic inhibitors on iron uptake from transferrin.”
“ Calcium significantly diminishes the absorption of ferrous and ferric iron in a dose-related manner, whether the test doses of calcium and radioiron are administered orally or introduced into isolated intestinal segments; the effect is maximal in the duodenum and jejunum.”
“In the presence of Ca2+ (10 mM) during the substitution process, Fe(II ) is not able to extract Mn at pH 5.7 and extracts only 1Mn at pH 6.5 (instead of two without Ca2+).”
“We found that Ca2+ cations (about 50 mM) inhibit the light-dependent oxidation of Fe(II) (5 µM) by about 25% in PSII(-Mn) membranes, whereas inhibition of the blocking process is greater at about 40%.”
Ca2+ effects on Fe(II) interactions with Mn-binding sites in Mn-depleted oxygen-evolving complexes of photosystem II and on Fe replacement of Mn in Mn-containing, Ca-depleted complexes.“The results … that ferrous … calcium had an antagonistic effect at Fe(II)/Ca molar ratio of lower than 1:4, but a synergistic effect at Fe(II)/Ca molar ratio of higher than 1:4, with the strongest synergistic effect at Fe(II)/Ca molar ratio of 7:3.”
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