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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Fentanyl and Magnesium



Research Papers that Mention the Interaction

Our hypothesis was that the addition of magnesium to postoperative epidural infusion of fentanyl may decrease the need for fentanyl.
British journal of anaesthesia  •  2007  |  View Paper
Coinjection of magnesium with fentanyl markedly enhanced the antinociception.
Magnesium may not only prevent the hyperalgesia but also enhance antinociceptive effect of fentanyl.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2009  |  View Paper
The fentanyl consumed in first 24 hours was significantly less in those patients who received lignocaine and magnesium [Group I (204.4 ± 136.4), Group II (383 ± 168.2), Group III (194 ± 148.9); (P = 0.01)].
Saudi journal of anaesthesia  •  2019  |  View Paper
The total postoperative consumption of fentanyl was significantly lower in the Magnesium group (42.4 ± 5.3) than that in the placebo group (94.4 ± 9.9), with a P value 0.
Journal of anaesthesiology, clinical pharmacology  •  2018  |  View Paper
Reduced fentanyl and rocuronium consumption in Mg group are compared to C (P = 0.00).
Saudi journal of anaesthesia  •  2016  |  View Paper
Conclusions: The administration of magnesium (75 mg) as an adjuvant to epidural fentanyl (1 μg/ kg) for postoperative analgesia results in significantly lower VRS with prolonged duration of analgesia as compared with epidural fentanyl (1 μg/kg) alone.
Saudi journal of anaesthesia  •  2012  |  View Paper