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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fenofibrate
supplement:
Vitamin E
Research Papers that Mention the Interaction
“CONCLUSIONS The combination of mi ronized fenofibrate 20 0 mg/day and vit amin E 40 0 IU/day tended to increase the resistance of non-HDL lipoproteins to copper-mediated oxidation, shown by a prolongation of the lag-time.”
“The lag-time increased further when fenofibrate and vitamin E were given in association. (”
“This protective effect of vitamin E tended to be amplified by micronized fenofibrate.”
Effects of micronized fenofibrate and vitamin E on in vitro oxidation of lipoproteins in patients with type 1 diabetes mellitus.“Three months of Vitamin E supplementation only improves LDL resistance to oxidation and addition to fenofibrate results in a slightly greater effect.”
“Coadministration of fenofibrate with α-tocopherol prolonged the lag phase to a greater extent than fenofibrate alone, showing a synergistic interaction between the two compounds.”
“Finally, the combination of fenofibrate and α-tocopherol was significantly more effective in modifying lipoprotein oxidation parameters than what was observed with α-tocopherol and bezafibrate or gemfibrozil.”
“Thus, in addition to its well-established effects on lipoprotein concentrations and atherogenic parameters, fenofibrate reduces the susceptibility of VLDL and LDL to oxidative modification and exerts its action synergistically with α-tocopherol.”
Fenofibrate protects lipoproteins from lipid peroxidation: Synergistic interaction with α-tocopherol
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