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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fenofibrate
supplement:
Asymmetric Dimethylarginine
Research Papers that Mention the Interaction
“8-week treatment with fenofibrate significantly reduced the elevated levels of ADMA (0.53±0.12 μmol/L, P<0.01), MDA and TNF-α, attenuated the decreased level of NO and improved endothelial function.”
Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia“… fenofibrate (… ADMA , LDH and TNF-α, attenuated the decreased levels of NO and the decreased activity of DDAH and prevented the activation of NF-κB. Similar …. The beneficial effects of fenofibrate on cultured endothelial cells were abolished by MK-886, a specific peroxisome proliferator-activated receptor-α (PPARα) antagonist.”
“Treatment with fenofibrate (30 or 100 mg/kg) significantly reduced the inhibition of vasodilator responses to acetylcholine, decreased the elevated levels of ADMA , MDA and TNF-α, and enhanced the decreased level of nitrite/nitrate in the rats treated with LDL.”
Effect of fenofibrate on LDL-induced endothelial dysfunction in rats
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