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Possible Interaction: Fenfluramine and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

Administration of DL-fenfluramine (20 mg/kg, i.p.) had no effect on the basal levels of ascorbic acid and hydroxyl radical, but significantly blocked ethanol-induced ascorbic acid release and increased hydroxyl radical levels significantly.
Exogenous administration of ascorbic acid (20 mg/kg, s.c.) increased the extracellular levels of ascorbic acid in the striatum, and inhibited the increase of 2,3- and 2,5-DHBA in DL-fenfluramine plus ethanol group.
Brain Research  •  2002  |  View Paper
In relation to the brain ascorbic acid level in the scorbutic gunieapigs, the initial stable level of brain ascorbic acid was significantly reduced by fenfluramine in both sexes by day 24, (P less than 0.05).
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  1981  |  View Paper
Brain ascorbic acid level in scorbutic guinea pigs was more significantly reduced by fenfluramine than by either Mazindol or Diethylpropion after 24 days administration.
Supplementary vitamin C reduced the anti-obesity actions of fenfluramine , Mazindol and Diethylpropion.
Acta vitaminologica et enzymologica  •  1981  |  View Paper
It has been shown that supplementary vitamin C can inhibit the anti-obesity and anorectic actions of fenfluramine and counteract its effect in raising tissue cholesterol.
International journal of obesity  •  1979  |  View Paper
Fenfluramine reduced hepatic and plasma AA significantly in comparison with the animals receiving the diet alone, or the diet with AA supplementation in the absence of fenfluramine administration.
It is concluded that AA release plays an important role in the anti-obesity and anorectic actions of fenfluramine.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  1979  |  View Paper