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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Fenfluramine
supplement:
Vitamin C
Research Papers that Mention the Interaction
“Administration of DL-fenfluramine (20 mg/kg, i.p.) had no effect on the basal levels of ascorbic acid and hydroxyl radical, but significantly blocked ethanol-induced ascorbic acid release and increased hydroxyl radical levels significantly.”
“Exogenous administration of ascorbic acid (20 mg/kg, s.c.) increased the extracellular levels of ascorbic acid in the striatum, and inhibited the increase of 2,3- and 2,5-DHBA in DL-fenfluramine plus ethanol group.”
Endogenous released ascorbic acid suppresses ethanol-induced hydroxyl radical production in rat striatum“In relation to the brain ascorbic acid level in the scorbutic gunieapigs, the initial stable level of brain ascorbic acid was significantly reduced by fenfluramine in both sexes by day 24, (P less than 0.05).”
“ Brain ascorbic acid level in scorbutic guinea pigs was more significantly reduced by fenfluramine than by either Mazindol or Diethylpropion after 24 days administration.”
“Supplementary vitamin C reduced the anti-obesity actions of fenfluramine , Mazindol and Diethylpropion.”
“It has been shown that supplementary vitamin C can inhibit the anti-obesity and anorectic actions of fenfluramine and counteract its effect in raising tissue cholesterol.”
“ Fenfluramine reduced hepatic and plasma AA significantly in comparison with the animals receiving the diet alone, or the diet with AA supplementation in the absence of fenfluramine administration.”
“It is concluded that AA release plays an important role in the anti-obesity and anorectic actions of fenfluramine.”
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