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Last Updated: 2 months ago

Possible Interaction: Fenfluramine and Tryptophan

supplement:

Tryptophan

Research Papers that Mention the Interaction

At typical doses for each of these compounds, neurochemical studies suggest a continuum of serotonergic enhancement from tryptophan through the SSRIs, fenfluramine and MDMA having the largest effect.
Biological Psychiatry  •  2010  |  View Paper
5-HT release after fluvoxamine and fenfluramine was significantly diminished in rats on a TRP low diet, and significantly enhanced after fenfluramine in rats on a TRP high diet.
Psychopharmacology  •  2004  |  View Paper
Finally, in a second set of mice, the same tryptophan diet was found to potentiate the aggression-reducing effects of fluoxetine and fenfluramine without disrupting motor performance.
Journal of studies on alcohol. Supplement  •  1993  |  View Paper
However, the tryptophan supplementation significantly enhanced the reduction in ethanol intake induced by fenfluramine and fluoxetine.
It appears that both fenfluramine and fluoxetine decrease ethanol intake more so than that of water or sucrose and that this effect is exacerbated by tryptophan supplementation.
Pharmacology Biochemistry and Behavior  •  1993  |  View Paper
Fenfluramine (8 mg/kg) significantly reduced ethanol consumption and tryptophan further significantly reduced ethanol intake.
Alcoholism, clinical and experimental research  •  1991  |  View Paper
Pretreatment of rats with the serotonin precursor L-tryptophan (100 mg/kg i.p.) potentiated the effect of a submaximal dose of fenfluramine (2 mg/kg i.p.) on plasma prolactin levels, but did not affect the corticosterone response.
Neuroendocrinology  •  1985  |  View Paper
of fenfluramine was potentiated by pretreatment with the precursor of serotonin L-tryptophan (100 mg/kg, i.p.).
Neuropharmacology  •  1985  |  View Paper
Tryptophan increased backward walking resulting from the injection of fenfluramine , but did not affect five other behaviours provoked.
Neuropharmacology  •  1981  |  View Paper
A single injection of fenfluramine hydrochloride resulted in a short-term increase in striate synaptosomal conversion of tryptophan to serotonin (5-HT) in rat brain.
The Journal of pharmacology and experimental therapeutics  •  1976  |  View Paper
In vitro, addition of fenfluramine into a synaptosomal fraction reduced uptake of 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, glutamic acid, tryptophan and tjrosine.
In vitro, addition of fenfluramine into a synaptosomal fraction reduced uptake of 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, glutamic acid, tryptophan and tjrosine. [
Neuropharmacology  •  1976  |  View Paper