supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
drug:
Fenfluramine
supplement:
Tryptophan
Research Papers that Mention the Interaction
“Baseline cortisol, prolactin, and L-tryptophan (L-TRP) availability may affect PRF and may also influence response to treatment.”
Baseline prolactin and L-tryptophan availability predict response to antidepressant treatment in major depression“At typical doses for each of these compounds, neurochemical studies suggest a continuum of serotonergic enhancement from tryptophan through the SSRIs, fenfluramine and MDMA having the largest effect.”
“5-HT release after fluvoxamine and fenfluramine was significantly diminished in rats on a TRP low diet, and significantly enhanced after fenfluramine in rats on a TRP high diet.”
Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats“Finally, in a second set of mice, the same tryptophan diet was found to potentiate the aggression-reducing effects of fluoxetine and fenfluramine without disrupting motor performance.”
“However, the tryptophan supplementation significantly enhanced the reduction in ethanol intake induced by fenfluramine and fluoxetine.”
“It appears that both fenfluramine and fluoxetine decrease ethanol intake more so than that of water or sucrose and that this effect is exacerbated by tryptophan supplementation.”
“of fenfluramine was potentiated by pretreatment with the precursor of serotonin L-tryptophan (100 mg/kg, i.p.).”
“ Tryptophan increased backward walking resulting from the injection of fenfluramine , but did not affect five other behaviours provoked.”
“In vitro, addition of fenfluramine into a synaptosomal fraction reduced uptake of 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, glutamic acid, tryptophan and tjrosine. [”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback