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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
drug:
Fenfluramine
supplement:
Tryptophan
Research Papers that Mention the Interaction
“At typical doses for each of these compounds, neurochemical studies suggest a continuum of serotonergic enhancement from tryptophan through the SSRIs, fenfluramine and MDMA having the largest effect.”
Is Ecstasy an Empathogen?“5-HT release after fluvoxamine and fenfluramine was significantly diminished in rats on a TRP low diet, and significantly enhanced after fenfluramine in rats on a TRP high diet.”
Effects of dietary tryptophan variations on extracellular serotonin in the dorsal hippocampus of rats“Finally, in a second set of mice, the same tryptophan diet was found to potentiate the aggression-reducing effects of fluoxetine and fenfluramine without disrupting motor performance.”
“However, the tryptophan supplementation significantly enhanced the reduction in ethanol intake induced by fenfluramine and fluoxetine.”
“It appears that both fenfluramine and fluoxetine decrease ethanol intake more so than that of water or sucrose and that this effect is exacerbated by tryptophan supplementation.”
“ Fenfluramine (8 mg/kg) significantly reduced ethanol consumption and tryptophan further significantly reduced ethanol intake.”
“Pretreatment of rats with the serotonin precursor L-tryptophan (100 mg/kg i.p.) potentiated the effect of a submaximal dose of fenfluramine (2 mg/kg i.p.) on plasma prolactin levels, but did not affect the corticosterone response.”
“of fenfluramine was potentiated by pretreatment with the precursor of serotonin L-tryptophan (100 mg/kg, i.p.).”
“ Tryptophan increased backward walking resulting from the injection of fenfluramine , but did not affect five other behaviours provoked.”
“A single injection of fenfluramine hydrochloride resulted in a short-term increase in striate synaptosomal conversion of tryptophan to serotonin (5-HT) in rat brain.”
“In vitro, addition of fenfluramine into a synaptosomal fraction reduced uptake of 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, glutamic acid, tryptophan and tjrosine.”
“In vitro, addition of fenfluramine into a synaptosomal fraction reduced uptake of 5-hydroxytryptamine, dopamine, γ-aminobutyric acid, glutamic acid, tryptophan and tjrosine. [”
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