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Possible Interaction: Fenfluramine and Glucose



Research Papers that Mention the Interaction

During the clamp, insulin metabolic clearance rate (MCR) was similar after both placebo and d-fenfluramine; endogenous (hepatic) glucose production was similarly and almost completely suppressed, whereas glucose disposal was remarkably enhanced after d-fenfluramine (average increase of glucose MCR 35 +/- 12%, P less than 0.02).
Diabetes Care  •  1991  |  View Paper
An increase in lactate production would indicate metabolism of the glucose entering the cell under the influence of fenfluramine.
Nature  •  1976  |  View Paper
The release of endogenous 5-HT following intraperitoneal administration of d-fenfluramine led to a significant increase in plasma levels of glucose and adrenaline.
Journal of Experimental Biology  •  2010  |  View Paper
D-Fenfluramine also decreased the incorporation of glucose into glyceride-glycerol, but this effect was less pronounced than that for fatty acid synthesis.
The incorporation of glucose into fatty acids by adipose tissue pieces decreased by 65-74% after treatment with D-fenfluramine.
Biochemical pharmacology  •  1989  |  View Paper
The emptying of normal saline was inhibited by fenfluramine as was the initial bolus phase of the emptying of glucose.
The American journal of physiology  •  1986  |  View Paper
Furthermore, fenfluramine was found to produce a significant thermogenic effect when accompanied with a glucose meal , but not with one consisting of fat.
International journal of obesity  •  1986  |  View Paper
Fenfluramine inhibits the formation of glucose from lactate plus pyruvate and from alanine as well as the production of ketone bodies from added oleate.
Biochemical pharmacology  •  1983  |  View Paper