Possible Interaction: Fenfluramine and Glucose

“During the clamp, insulin metabolic clearance rate (MCR) was similar after both placebo and d-fenfluramine; endogenous (hepatic) glucose production was similarly and almost completely suppressed, whereas glucose disposal was remarkably enhanced after cMenfluramine (average increase of glucose MCR 35 ± 12%, P < 0.02).”

“In rodents glucose appears to enhance the toxic effects of fenfluramine , which suggests that it is unlikely to have a therapeutic role in severe intoxication in humans.”

“An increase in lactate production would indicate metabolism of the glucose entering the cell under the influence of fenfluramine.”

“In rodents glucose appears to enhance the toxic effects of fenfluramine , which suggests that it is unlikely to have a therapeutic role in severe intoxication in humans.”

“In rodents glucose appears to enhance the toxic effects of fenfluramine , which suggests that it is unlikely to have a therapeutic role in severe intoxication in humans.”

“The release of endogenous 5-HT following intraperitoneal administration of d-fenfluramine led to a significant increase in plasma levels of glucose and adrenaline.”

“ D-Fenfluramine also decreased the incorporation of glucose into glyceride-glycerol, but this effect was less pronounced than that for fatty acid synthesis.”

“The incorporation of glucose into fatty acids by adipose tissue pieces decreased by 65-74% after treatment with D-fenfluramine.”

“ Basal glucose turnover was reduced 28% (P < .05) in fat-fed rats receiving d-fenfluramine (fat+fen).”

“The emptying of normal saline was inhibited by fenfluramine as was the initial bolus phase of the emptying of glucose.”

“Furthermore, fenfluramine was found to produce a significant thermogenic effect when accompanied with a glucose meal , but not with one consisting of fat.”