Possible Interaction: Fenfluramine and Glucose

“During the clamp, insulin metabolic clearance rate (MCR) was similar after both placebo and d-fenfluramine; endogenous (hepatic) glucose production was similarly and almost completely suppressed, whereas glucose disposal was remarkably enhanced after d-fenfluramine (average increase of glucose MCR 35 +/- 12%, P less than 0.02). ”

“An increase in lactate production would indicate metabolism of the glucose entering the cell under the influence of fenfluramine.”

“The release of endogenous 5-HT following intraperitoneal administration of d-fenfluramine led to a significant increase in plasma levels of glucose and adrenaline.”

“ D-Fenfluramine also decreased the incorporation of glucose into glyceride-glycerol, but this effect was less pronounced than that for fatty acid synthesis.”

“The incorporation of glucose into fatty acids by adipose tissue pieces decreased by 65-74% after treatment with D-fenfluramine.”

“The emptying of normal saline was inhibited by fenfluramine as was the initial bolus phase of the emptying of glucose.”

“Furthermore, fenfluramine was found to produce a significant thermogenic effect when accompanied with a glucose meal , but not with one consisting of fat.”

“ Fenfluramine inhibits the formation of glucose from lactate plus pyruvate and from alanine as well as the production of ketone bodies from added oleate.”