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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Fendiline
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“These findings are explained by the antagonistic effect of fendiline to Ca++ , which activates the guanylate cyclase and inhibits the adenylate cyclase.”
The influence of the calcium antagonist fendiline on tone and motility of the guinea pig gut smooth muscle and the cAMP and cGMP concentrations of the isolated terminal ileum.“This suggests that fendiline triggered external Ca2+ influx and internal Ca2+ release.”
Fendiline increases [Ca2+]i in Madin Darby canine kidney (MDCK) cells by releasing internal Ca2+ followed by capacitative Ca2+ entry.“Verapamil did not change the time course of the current, whereas fendiline accelerated its decay when either Ca++ or Ba++ ions were used as charge carriers.”
“ Calcium most effectively antagonizes the inhibitory effect of fendiline on spontaneous rhythmic activity.”
“The finding that certain types of activation, after the inhibitory action of fendiline , occur to a different degree by addition of calcium to the medium, are also indirect confirmation of the existence of different calcium channels.”
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