Possible Interaction: Fenclonine and Tryptophan

“ pCPA counteracted only the enhancement of the catalepsy observed after TP administration.”

“ PCPA inhibits brain tryptophan 5-monooxygenase and can produce a reduction in whole brain serotonin.”

“L-Dopa, dl-amphetamine, alpha-methyl-Dopa, parachlorophenylalanine and serotonino-blockators--deseryl and lysergide--eliminate the tranquilizing action of tryptophane on emotional reactivity, decreasing serotonin accumulation and intensifying the formation of 5-oxyindolacetic acid.”

“The accelerating effect of tryptophan on tolerance and dependence development in mice was antagonized by pretreatment with the tryptophan hydroxylase inhibitor, p-chlorophenylalanine.”

“ Para-chlorophenylalanine will inhibit the 5hydroxylation of tryptophan but has little effect upon flushing, although it usually relieves diarrhoea.”

“ Para-chlorophenylalanine will inhibit the 5hydroxylation of tryptophan but has little effect upon flushing, although it usually relieves diarrhoea.”

“Pretreatment with ip p‐CPA blocked the effects of TRP on thermoregulation and performance.”

“This response is modulated by serotonergic pathways, because TRP effects were blocked in the presence of p‐CPA.”

“The inhibitory effect of tryptophan and chlorimipramine was abolished by pretreatment with p-chlorophenylalanine , while that of LSD was not.”

“An antianxiety-like effect was observed for TRP only at 250 mg/kg dose together with p-CPA pretreatment, while no sedative effect was observed at all.”

“2/6 of the animals treated with 1% Trp and 1/6 treated with 5% Trp for 3 weeks and 2/4 animals treated with 1% Trp and 1/4 treated with 5% Trp for 12 weeks died after injection of p-CPA.”