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“Depletion of hypothalamic 5‐HT (−93%) by pretreatment of the animals with para‐chlorophenylalanine (p‐CPA), resulted in a halved ACTH response to LPS, despite an overall unchanged secretory pattern.”
“The ACTH and corticosterone levels augment by L-5HTP and decrease by pCPA in all age groups, but this corresponding increase or decrease was less marked in the older rats.”
Revista espanola de fisiologia • 1991 | View Paper
“Treatment with p-chlorophenylalanine did not affect the daily rise in circulating ACTH levels but did abolish the rhythm in adrenal responsiveness to ACTH.”