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Last Updated: 3 months ago

Possible Interaction: Felodipine and Naringenin

supplement:

Naringenin

Research Papers that Mention the Interaction

The flavonoid naringin is the most abundant natural product specific for grapefruit and related citrus--the aglycone naringenin , known to be readily formed from naringin in humans, was found to inhibit the oxidation of the dihydropyridines nifedipine and felodipine in human liver microsomal preparations.
Carcinogenesis  •  1990  |  View Paper
The co-administration of naringenin significantly elevated the Cmax and increased the AUCtotal of felodipine in dose-dependent manner.
The permeability of felodipine was increased in presence of naringenin and ritonavir (standard P-glycoprotein (P-gp) and Cytochrome P450 (CYP)3A4 inhibitor).
These results suggest that naringenin significantly increased the Cmax and AUC of felodipine is due to P-gp and CYP3A4 inhibition.
Drug development and industrial pharmacy  •  2014  |  View Paper