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Discover Supplement-Drug Interactions

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Last Updated: 18 days ago

Possible Interaction: Felodipine and Hesperetin



Research Papers that Mention the Interaction

Concurrent use of hesperetin dramatically altered the pharmacokinetics of felodipine leading to an increase in systemic exposure.
The area under the plasma concentration–time curve (AUC0–∞) and the peak plasma concentration (Cmax) of felodipine were dose‐dependently increased in SDS and MDS with hesperetin compared to control ( p < 0.001).
The in vitro experiments revealed that the verapamil and hesperetin increased the intestinal absorption of felodipine (p < 0.01).
Phytotherapy research : PTR  •  2014  |  View Paper