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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Felodipine
supplement:
Hesperetin
Research Papers that Mention the Interaction
“Concurrent use of hesperetin dramatically altered the pharmacokinetics of felodipine leading to an increase in systemic exposure.”
“The area under the plasma concentration–time curve (AUC0–∞) and the peak plasma concentration (Cmax) of felodipine were dose‐dependently increased in SDS and MDS with hesperetin compared to control ( p < 0.001).”
“The in vitro experiments revealed that the verapamil and hesperetin increased the intestinal absorption of felodipine (p < 0.01).”
Evaluation of First‐Pass Cytochrome P4503A (CYP3A) and P‐glycoprotein Activities Using Felodipine and Hesperetin in Combination in Wistar Rats and Everted Rat Gut Sacs in Vitro
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