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“ Grapefruit … felodipine AUC0–8 (25 vs. 13 ng.h/mL, P < 0.001) and Cmax (5.8 vs. 2.7 ng/mL, P < 0.001) and …–8 ratio (0.84 vs. 1.29, P < 0.001), while the three coffees caused no change in these parameters compared to water.”
Pharmacology research & perspectives • 2017 | View Paper
“ Felodipine AUC (r = 0.73, P < 0.01) and Cmax (r = 0.69, P < 0.02) correlated between grapefruit juice treatments among individuals.”
“The % increase in felodipine AUC with the initial grapefruit juice treatment compared with water correlated with the % increase in felodipine Cmax among individuals (r = 0.80, P < 0.01).”
British journal of clinical pharmacology • 1995 | View Paper
“The issue of food-drug interactions first became widely known in 1989 when grapefruit was first found to increase the blood levels of felodipine , a calcium channel blocker, and later, in 1996, terfenadine, a non-sedative antihistamine.”