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Discover Supplement-Drug Interactions

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Last Updated: 21 days ago

Possible Interaction: Felodipine and Grapefruit Extract

Research Papers that Mention the Interaction

Grapefruit … felodipine AUC0–8 (25 vs. 13 ng.h/mL, P < 0.001) and Cmax (5.8 vs. 2.7 ng/mL, P < 0.001) and …–8 ratio (0.84 vs. 1.29, P < 0.001), while the three coffees caused no change in these parameters compared to water.
Pharmacology research & perspectives  •  2017  |  View Paper
Felodipine AUC (r = 0.73, P < 0.01) and Cmax (r = 0.69, P < 0.02) correlated between grapefruit juice treatments among individuals.
The % increase in felodipine AUC with the initial grapefruit juice treatment compared with water correlated with the % increase in felodipine Cmax among individuals (r = 0.80, P < 0.01).
British journal of clinical pharmacology  •  1995  |  View Paper
The issue of food-drug interactions first became widely known in 1989 when grapefruit was first found to increase the blood levels of felodipine , a calcium channel blocker, and later, in 1996, terfenadine, a non-sedative antihistamine.
Molecular nutrition & food research  •  2008  |  View Paper