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Discover Supplement-Drug Interactions

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Last Updated: 5 months ago

Possible Interaction: Felodipine and Grapefruit Extract

Research Papers that Mention the Interaction

Grapefruit … felodipine AUC0-8 (25 vs. 13 ng.h/mL, P < 0.001) and Cmax (5.8 vs. 2.7 ng/mL, P < 0.001) and …-8 ratio (0.84 vs. 1.29, P < 0.001), while the three coffees caused no change in these parameters compared to water.
Pharmacology research & perspectives  •  2017  |  View Paper
RESULTS Felodipine AUC with commercial grapefruit juice, grapefruit segments, or grapefruit extract was on average 3-fold higher than that with water.
Clinical pharmacology and therapeutics  •  2000  |  View Paper
The issue of food-drug interactions first became widely known in 1989 when grapefruit was first found to increase the blood levels of felodipine , a calcium channel blocker, and later, in 1996, terfenadine, a non-sedative antihistamine.
Molecular nutrition & food research  •  2008  |  View Paper