Possible Interaction: Felodipine and Calcium Supplement

“The plasma calcium concentration was significantly higher during felodipine treatment than during placebo and this was accompanied by an increased urinary calcium excretion.”

“The effect of calcium (Ca2+) antagonism with felodipine on the intracellular concentrations and transmembrane fluxes of cations in erythrocytes, was studied in 10 normal volunteers at rest and during exercise.”

“Plasma calcium levels rose during felodipine therapy.”

“ Calcium ionophore-induced histamine release was reduced or blocked by calmidazolium, CGS 9343B, felodipine , metofenazate, and Ro 22-4839.”

“Zinc and H+ are capable of producing similar potentiations of felodipine binding (half-maximal at 570 microM, and pH 5.8), but only in the presence of calcium.”

“ Felodipine is a dihydropyridine that blocks the slow entry channel for calcium.”

“Inhibition of intracellular calcium increases wasachieved using nM concentrations of felodipine or amlodipine. ”

“Inhibition of intracellular calcium increases wasachieved using nM concentrations of felodipine or amlodipine.”

“This result suggests that felodipine may inhibity Ca++ release from intracellular Ca++ stores through a mechanism of Ca++ or inositol 1,4,5-triphosphate induced Ca++ release in addition to a blockade of Ca++ influx through the sarcolemma.”

“ Felodipine , a Ca antagonist (10(-4)M), had no effect on the basal release of [3H]NA whereas it reduced the overflow of transmitter caused by KCl or Ca.”