Possible Interaction: Felodipine and Calcium Supplement

“The plasma calcium concentration was significantly higher during felodipine treatment than during placebo and this was accompanied by an increased urinary calcium excretion.”

“The effect of calcium (Ca2+) antagonism with felodipine on the intracellular concentrations and transmembrane fluxes of cations in erythrocytes, was studied in 10 normal volunteers at rest and during exercise.”

“ Felodipine is a dihydropyridine that blocks the slow entry channel for calcium.”

“The negative myocardial effect of felodipine , attainable only in vitro, is characterised by surmountable antagonism of the inotropic response to added adrenergic agonists or Ca2+ and is compatible with calcium influx inhibition.”

“ Felodipine inhibited the initial rate of ATP-driven calcium uptake but failed to affect the initial rate of mitochondrial calcium transport.”

“Inhibition of intracellular calcium increases wasachieved using nM concentrations of felodipine or amlodipine.”

“Compared with vehicle alone, felodipine significantly increased NOx generation, Ca2+ -dependent NOS activity, and eNOS protein mass in proliferating and quiescent endothelial cells.”

“ Felodipine inhibited both L-type Ca2+ channel currents (ICa) and cell contractions in a concentration-dependent manner (10 pM to 100 nM) when we used a holding potential of -80 mV or -40 mV. The potency of felodipine was sharply dependent on a holding potential.”

“ Felodipine (100 nM) caused a gradual decrease in the amplitude of the spontaneous phasic contractions in a calcium-containing medium.”

“ Felodipine selectively decreased the sustained, but not the transient, type of calcium current in a whole-cell voltage clamp of azygos venous muscle cells.”