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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Felodipine and Bergamot



Research Papers that Mention the Interaction

RESULTS Grapefruit juice (containing 1.7 mg bergamottin ) increased peak plasma concentration (C max ) and area under the plasma concentration-time curve (AUC) of felodipine by 89% (P < .025) and 54% (P < .025), respectively, compared with water.
With 2 mg bergamottin, felodipine C max increased by 33% (P < .05).
With 6 mg bergamottin, felodipine C max was enhanced by 35% (P < .025), and with 12 mg bergamottin, felodipine C max increased by 40% (P < .05) and AUC increased by 37% (P < .05) compared with water.
Clinical pharmacology and therapeutics  •  2004  |  View Paper