Possible Interaction: Fatty Acids, Omega-3 and Thioguanine

“Single blind administration of EPA-rich omega-3 fatty acids at 3 dose levels of 3g, 6g and 12g/d (each dose lasting 3 weeks was separated by 2 weeks on placebo) lowered plasma TG levels and lecithin cholesterol acyltransferase-molar esterification rate (LCAT-MER) activity (6.12g/d).”

“In the linear regression analysis, the lipid-lowering effect of ω-3 fatty acids was greater when baseline TG or non-HDL-C levels were high and body mass index was low.”

“Laboratory examinations showed a TG level of 4520 mg/dL which was reduced with a low-fat diet, MCT oil-rich formula and omega-3 fatty acid supplementation.”

“Although omega-3 fatty acids are efficacious in lowering TG levels and may have pleiotropic effects such as reducing plaque instability and proinflammatory mediators of atherogenesis, clinical outcomes data are currently lacking.”

“Prescription formulations of omega-3 fatty acids (OM3FAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), reduce plasma TG levels and are approved for the treatment of patients with severe hypertriglyceridemia.”

“Early diet treatment and omega-3 supplementa-tion seems to be effective in the lowering of TG levels.”

“ Omega-3 fatty acids (n3-FA) lower fasting TG levels.”

“ Omega-3 FA significantly lowered TG (47.1%; p < 0.05), but left TC, LDL-C and HDL-C unchanged.”