Possible Interaction: Fatty Acids, Omega-3 and Simvastatin

“…,omega-3 fatty acids given … to simvastatin to patients with combined hyperlipemia reduced the free tissue factor pathway inhibitor fraction in the fasting state and inhibited the activation … factor VII occurring during postprandial lipemia, thus representing a potential beneficial effect on the hemostatic risk profile in this patient group.”

“In addition, omega-3 EEC 4000 mg/day plus simvastatin or atorvastatin reduced triglyceride, non-high-density lipoprotein cholesterol (non-HDL-C) and/or very-low-density lipoprotein cholesterol (VLDL-C) levels to a significantly greater extent than placebo plus simvastatin or atorvastatin.”

“In one study, the primary endpoint of non-HDL-C levels was reduced by a significantly greater extent with omega-3 EEC plus simvastatin than with placebo plus simvastatin.”

“Conclusion:The combination of omega-3 fatty acids plus simvastatin , which achieved a significantly greater reduction of triglycerides without adverse reactions, should be considered as an optimal treatment option for patients with mixed dyslipidemia.”

“The recently completed Combination of Prescription Omega-… With Simvastatin (COMBOS) study confirmed that prescription omega-3 fatty acid administered in combination with simvastatin achieves statistically significant improvements across a range of lipid indicators beyond the LDL primary target, including triglycerides, non-high-density lipoprotein cholesterol, and lipoprotein particle size.”