Possible Interaction: Fatty Acids, Omega-3 and Linoleic Acid

“We observed a 2.7-fold increase in the omega-6/omega-3 ratio in tumors from LA diet-fed mice and a 4.2-fold decrease in the ratio in tumors from the SDA diet-fed mice.”

“Therefore, to study whether or not the protumorigenic role of 15-LO-1 and dietary omega-6 LA can be modulated by altering omega-3 levels through diet, we surgically removed tumors caused by LAPC-4 cells (mouse model to simulate radical prostatectomy).”

“This was associated with reduced levels of linoleic acid and arachidonic acid in adipose tissue and tumour lipids with incorporation of n-3 fatty acids (all p less than 0.01 at least, analysis of variance).”

“In conclusion, in our cross-sectional community-based study, we found several associations consistent with the notion of protective effects of omega-3 and linoleic acid.”

“The main argument was that the biological availability of longer chain PUFA of the n-3 class was compromised by excess linoleic acid and that the cardioprotective advantage of n-3 fatty acids was diminished by linoleic acid.”

“Diets high in omega-3 fatty acids and fish were inversely associated with risk for AMD when intake of linoleic acid was low.”

“… omega-3 fatty acid (docosahexanoic acid, DHA) is known to … of omega-6 polyunsaturated fatty acid ( LA ), we wanted to see whether addition of DHA can inhibit the growth of MCF-7 cells … LA + E2 and any alteration of BRCA1 mRNA expression could be seen in DHA treated culture.”

“ Linoleic acid stimulated, and the omega-3 fatty acids inhibited, tumor cell invasion at concentrations of 0.25 and 0.5 microgram/ml.”

“The potency of n-3 fatty acids , which are present in relatively high concentrations in fish oils, is at least one order of magnitude greater than that of LA.”

“A rapid incorporation of omega 3 fatty acids in plasma lipids and in erythrocyte phosphatidyl choline, at the expense of linoleic acid , was seen, resulting in increased total unsaturation.”