Possible Interaction: Fatty Acids, Omega-3 and Leukotriene B4

“Dietary supplementation with n-3 polyunsaturated fatty acids thus significantly reduces formation of leukotriene B 4 from activated neutrophils at the expense of leukotriene B 5.”

“In the placebo group there was a 2% increase in leukotriene B 4 formation, while in contrast n-3 fatty acids led to a 34% decrease in formation of leukotriene B 4.”

“ Serum leukotriene B4 (LTB4) levels were significantly reduced by n-3 fatty acids , mean reduction (-177 pg/mL) compared to n-6 fatty acids (+63 pg/mL) P < 0.05.”

“This therapeutic mechanism formed one rationale for examining the effect of n-3 fatty acids , which also inhibit leukotriene B4 formation , on the course of these diseases.”

“The dietary introduction of n-3 fatty acids , such as EPA, may reduce the epidermopoiesis and neutrophil migration evoked by LTB4 through decreases in generation of LTB4 and the capacity of LTB5 to inhibit the effects of LTB4.”

“On the one hand, omega-3 fatty acids inhibit the formation of omega-6 fatty acids-derived pro-inflammatory eicosanoids (e.g. PGE2 and LTB4 ), and on the other hand these fatty acids can form several potent anti-inflammatory lipid mediators (e.g. resolvins and protectins).”

“It is believed that the decreased formation of LTB4 and TXA2 during sepsis after administration of omega-3-fatty acids accounts for improved microcirculatory perfusion and declined lactate acidosis.”

“Individual administration of celecoxib revealed significant reductions in PGE2 and PAF levels (P <0.05), while omega-3 fatty acid provided significant reduction in PGE2, PGF2alpha, and LTB4 levels compared to the LPS group (P <0.05).”

“The present study also suggests that dietary supplementation with n-3 fatty acids suppress intestinal PAF and LTB4 generation in hypoxia-induced bowel necrosis.”