Possible Interaction: Fatty Acids, Omega-3 and Leukotriene B4

“Dietary supplementation with n-3 polyunsaturated fatty acids thus significantly reduces formation of leukotriene B 4 from activated neutrophils at the expense of leukotriene B 5.”

“On the one hand, omega-3 fatty acids inhibit the formation of omega-6 fatty acids-derived pro-inflammatory eicosanoids (e.g. PGE2 and LTB4 ), and on the other hand these fatty acids can form several potent anti-inflammatory lipid mediators (e.g. resolvins and protectins).”

“It is believed that the decreased formation of LTB4 and TXA2 during sepsis after administration of omega-3-fatty acids accounts for improved microcirculatory perfusion and declined lactate acidosis.”

“… Ω-3 fatty acids inhibit the expression of receptors … of PMNs, FMLP and LTB4 , as well as the [Ca2+]i rise in response to those two stimuli, we propose that the antiinflammatory … EPA and DHA may be attributed, at least in part, to alteration in membrane activation of phagocytes.”

“This therapeutic mechanism formed one rationale for examining the effect of n-3 fatty acids , which also inhibit leukotriene B4 formation, on the course of these diseases.”

“The dietary introduction of n-3 fatty acids , such as EPA, may reduce the epidermopoiesis and neutrophil migration evoked by LTB4 through decreases in generation of LTB4 and the capacity of LTB5 to inhibit the effects of LTB4.”

“Individual administration of celecoxib revealed significant reductions in PGE2 and PAF levels (P <0.05), while omega-3 fatty acid provided significant reduction in PGE2, PGF2alpha, and LTB4 levels compared to the LPS group (P <0.05).”