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Discover Supplement-Drug Interactions
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Last Updated: 2 months ago
supplement:
Fatty Acids, Omega-3
drug:
Leptin
Research Papers that Mention the Interaction
“Our analysis showed that omega-3 supplementation significantly reduces leptin levels (mean difference (MD) = -1·71 ng/ml 95% confidence interval (CI): -3·17 to -0·24, P = 0·022).”
“Subgroup analysis based … showed that the omega-3 … leptin when used for nonobese subjects (MD = -3·60 ng/ml; 95% CI -6·23 to -0·90; P = 0·011); … not true for obese participants (MD = -0·86 ng/ml; 95% CI: -2·63 to -0·90; P = 0·296).”
Does omega‐3 fatty acids supplementation affect circulating leptin levels? A systematic review and meta‐analysis on randomized controlled clinical trials“ Omega-3 was observed to decrease circulating levels of leptin in non-obese subjects; however, omega-3-associated increases in leptin levels have been observed in obese subjects.”
“ Omega-3 was observed to decrease circulating levels of leptin in non-obese subjects; however, omega-3-associated increases in leptin levels have been observed in obese subjects.”
“In a review by Gray et al., omega-3 is observed to decrease circulating levels of leptin in non-obese subjects while omega-3-associated increases in leptin levels have been claimed in obese subjects [5].”
“Second, as mentioned in many studies, dietary intake of some food groups and supplements including fatty acids (particularly omega-3 fatty acid ) can affect plasma leptin levels [5].”
“BackgroundThe expression of leptin is increased in obesity and inhibited by n-3 polyunsaturated fatty acids (n-3 PUFAs), but the underlying molecular mechanisms have not been firmly established.”
The Regulation of Leptin, Leptin Receptor and Pro-opiomelanocortin Expression by N-3 PUFAs in Diet-Induced Obese Mice Is Not Related to the Methylation of Their Promoters“In non-obese subjects, omega-3 is observed to decrease circulating levels of leptin ; however, omega-3-associated increases in leptin levels have been observed in obese subjects.”
“Oleic acid or n-3 fatty acids downregulate the expression of leptin , fatty acid synthase and lipoprotein lipase in retroperitoneal adipose tissue.”
Veterinary aspects and perspectives of nutrigenomics: a critical review.
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