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Last Updated: 2 months ago

Possible Interaction: Fatty Acids, Omega-3 and Fluoxetine

Research Papers that Mention the Interaction

For instance, … recent study omega-3 fatty acids when administered … conjunction with fluoxetine decreased the Hamilton Rating Scale for Depression scores by greater than half in 81% of patients in comparison … a similar decline in only 50% of the patients who were administered fluoxetine only (Jazayeri et al., 2008).
Progress in Neuro-Psychopharmacology and Biological Psychiatry  •  2008  |  View Paper
Although individual treatments had no effects on DPA concentration, DPA increase was higher when omega-3 were combined with the non-antidepressant dose of fluoxetine.
Either antidepressant (10 mg/kg day) or non-antidepressant (1 mg/kg day) doses of fluoxetine in combination with omega-3 fatty acids increased hippocampal docosapentaenoic acid (DPA, 22:5 omega-3) levels.
Our results suggest no pharmacokinetic interaction and reveal specific hippocampal DPA changes after fluoxetine and omega-3 combined treatments in our experimental conditions.
The DPA role in the synergistic effect of fluoxetine and omega-3 combined treatments will be for sure the focus of future studies.
We previously reported that combined fluoxetine administration at antidepressant doses renders additive antidepressant effects, whereas non-antidepressant doses potentiate the omega-3 fatty acid antidepressant effect.
Journal of pharmaceutical sciences  •  2014  |  View Paper
Fluoxetine or mirtazapine at antidepressant doses (10 and 20 mg/kg/day, respectively) rendered additive effects in combination with omega-3 fatty acid supplementation (720 mg/kg/day).
European journal of pharmacology  •  2010  |  View Paper
However, in chronic study, omega-3 fatty acids affect the immobility and swimming behavior significantly … < 0.01) without any significant effect on climbing behavior and the efficacy of combination of omega-3 fatty acids … fluoxetine is significantly more than that of fluoxetine … activity of rats in forced swimming test.
It leads to the conclusion that omega-3 fatty acids have antidepressant activity per se, and the combination of fluoxetine and omega-3 fatty acids has more antidepressant efficacy than fluoxetine alone in forced swimming test in Wistar rats.
Acta poloniae pharmaceutica  •  2007  |  View Paper