Possible Interaction: Fatty Acids, Omega-3 and Fatty Acids, Omega-6

“The results showed that the 3 months' dietary supplementation with a combination of omega 3 and omega 6 fatty acids significantly reduced WBC aggregation to FMLP in healthy volunteers when compared to placebo.”

“These ω-3 fatty acids interact metabolically with ω-6 fatty acids mainly linoleic acid from corn oil, sunflower oil and peanut oil.”

“Contrastingly, there is also evidence that a high omega-6 fatty acid diet inhibits the anti-inflammatory and inflammation-resolving effect of the omega-3 fatty acids.”

“Recent studies also indicate that omega-3 and -6 fatty acids act in a competitive manner to generate mediators for energy metabolism, influencing feeding behavior, neural plasticity, and memory during aging.”

“We emphasize that the effect of omega-3 FA may depend on their balance with other dietary compounds, particularly omega-6 FA , which compete for the same pathways, thus modulating the production of metabolites.”

“However, Western countries have a diet rich in omega-6 fatty acids , which interfere with the health benefits of omega-3 fatty acids because they compete for the same rate-limiting enzymes.”

“Experimental studies have suggested that omega-6 and omega-3 fatty acids elicit divergent effects on body fat gain through mechanisms of adipogenesis, browning of adipose tissue, lipid homeostasis, brain-gut-adipose tissue axis, and most importantly systemic inflammation.”

“Despite increased consumption of PUFA at the present time the ratio of omega-6 and omega-3 fatty acids in the diet is not optimal.”

“High dietary intake of n-6 fatty acids in relation to n-3 fatty acids may generate health disorders, such as cardiovascular and other chronic diseases.”

“Inadequate intakes of omega-3 fatty acids decrease DHA and increase omega-6 fatty acids in the brain.”