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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Fatty Acids, Omega-3
supplement:
Docosahexaenoic Acid
Research Papers that Mention the Interaction
“We propose that CYP-dependent epoxy-metabolites of EPA and DHA may function as mediators of the vasodilatory and cardioprotective effects of omega-3 fatty acids and could serve as biomarkers in clinical studies investigating the cardiovascular effects of EPA/DHA supplementation.”
Dietary omega-3 fatty acids modulate the eicosanoid profile in man primarily via the CYP-epoxygenase pathway[S]“ Omega-3 DHA modulates different signaling pathways involved in carcinogenesis.”
“Some studies have shown that supplementing diets with n-3 polyunsaturated fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [ DHA ]) lowers systemic levels of key proinflammatory cytokines associated with inflammaging.”
“Background aimsDietary omega-6 and omega-3 fatty acids have remarkable impacts on the levels of DHA in the brain and retina.”
“Initially, Horrobin hypothesized that a low incidence of asthma in Inuit people was linked … fish, rich in omega-3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid DHA ]) [1], which … with omega-3 fatty acids can reduce bronchial inflammation, arachidonic acid (AA) … the late airway response to allergen exposure.”
“The omega-3 supplementation in Canadian women increased DHA and decreased LA levels to approach those in Greenland Inuit and raised EPA levels to surpass (45% higher) those in Greenland women (P < 0.0001).”
“The combined vitamin B12 and omega-3 fatty acid supplementation further enhanced the levels of DHA (P < 0.05) and BDNF (P < 0.05) in the hippocampus and CREB mRNA (P < 0.01) in the cortex as compared with BS group.”
Beneficial effects of omega-3 fatty acids and vitamin B12 supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second-generation Wistar rats.“This suggests that the ingestion of large amounts of DHA oil enhances lipid peroxidation in the target membranes where greater amounts of n-3 fatty acids are incorporated, thereby increasing the peroxidizability and possibly accelerating the atherosclerotic process.”
“The omega-3 products in the market have relative percentage variability that affects the purification formulas of EPA and DHA , which often cause very large price variations.”
Quantitative determination of EPA and DHA in fish oil capsules for cardiovascular disease therapy in Indonesia by GC-MS“Enrichment of omega-3 fatty acids indicated a significant increase in fatty acid bioconversion (ALA 32.2 ± 0.42%, EPA 7.9 ± 0.1%, and DHA 4.09 ± 0.2%) by 2.5-fold.”
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