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Possible Interaction: Fatty Acids, Omega-3 and Doconexent

Research Papers that Mention the Interaction

We propose that CYP-dependent epoxy-metabolites of EPA and DHA may function as mediators of the vasodilatory and cardioprotective effects of omega-3 fatty acids and could serve as biomarkers in clinical studies investigating the cardiovascular effects of EPA/DHA supplementation.
Journal of Lipid Research  •  2014  |  View Paper
Some studies have shown that supplementing diets with n-3 polyunsaturated fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [ DHA ]) lowers systemic levels of key proinflammatory cytokines associated with inflammaging.
Prostaglandins, leukotrienes, and essential fatty acids  •  2018  |  View Paper
Background aimsDietary omega-6 and omega-3 fatty acids have remarkable impacts on the levels of DHA in the brain and retina.
Nutrition Journal  •  2015  |  View Paper
Initially, Horrobin hypothesized that a low incidence of asthma in Inuit people was linked … fish, rich in omega-3 fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid DHA ]) [1], which … with omega-3 fatty acids can reduce bronchial inflammation, arachidonic acid (AA) … the late airway response to allergen exposure.
Expert review of respiratory medicine  •  2013  |  View Paper
The omega-3 supplementation in Canadian women increased DHA and decreased LA levels to approach those in Greenland Inuit and raised EPA levels to surpass (45% higher) those in Greenland women (P < 0.0001).
Nutrition  •  2002  |  View Paper
Since omega-3 … acid, DHA ) is known to … effect of omega-6 polyunsaturated fatty acid (LA), we wanted to see whether addition of DHA can inhibit the growth of MCF-7 cells … to LA + E2 and any alteration of BRCA1 mRNA expression could be seen in DHA treated culture.
Cancer biotherapy & radiopharmaceuticals  •  2001  |  View Paper
Omega-3 DHA modulates different signaling pathways involved in carcinogenesis.
Anti-cancer agents in medicinal chemistry  •  2020  |  View Paper
Enrichment of omega-3 fatty acids indicated a significant increase in fatty acid bioconversion (ALA 32.2 ± 0.42%, EPA 7.9 ± 0.1%, and DHA 4.09 ± 0.2%) by 2.5-fold.
BioMed research international  •  2017  |  View Paper
ResultsIn the neonates from the group fed with n-3 LC-PUFA , the DHA level in gastric content (+65%, P < 0.0001) and brain glial cell PE (+18%, P = 0.0001) and PS (+15%, P = 0.0009) were significantly increased compared to the ALA group.
Nutrition & metabolism  •  2010  |  View Paper
Regarding fatty acid composition of meat, GP inclusion in piglets' diet increased significantly n-3 fatty acids (EPA; C20 : 5n-3, DHA ; C22 : 6n-3, α-linolenic acid; C18 : 3n-3) and decreased significantly n-6/n-3 ratio compared with control (P<0.05).
Animal : an international journal of animal bioscience  •  2018  |  View Paper
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