Possible Interaction: Fatty Acids, Monounsaturated and Polyunsaturated Fatty Acids

“In conclusion, in an NCEP Step 1 diet containing 30% total fat, … other known cholesterol-influencing dietary factors held constant, the substitution of polyunsaturated fatty acid … monounsaturated fatty acid from 3% to 14% resulted in a progressive decline in … cholesterol and less triacylglycerol elevations, without effect on HDL cholesterol.”

“The proportion of PUFA in a MUFA diet appears to be a major determinant of the relative lipoprotein response to such a diet.”

“Furthermore, MUFA appear to result in a smaller PYY response compared with SFA and PUFA.”

“Transgenic mice fed MUFA and PUFA diets also had significantly higher liver TC (P = 0·020 and P = 0·002 respectively) and EC (P = 0·040 and P = 0·036 respectively) than controls fed the same diets.”

“Regarding saturated fatty acid, the polyunsaturated to monounsaturated (P.M.S) ratio was lower than the recommended ratio of 1:1:1 in 96% of samples.”

“Inverse associations were observed between MUFA (0.80, 0.67-0.96) and PUFA (0.84, 0.80-0.90) intakes and stroke mortality.”

“Higher intake of trans fat was associated with a 2.3-fold higher odds … presence of AMD (P for trend = 0.0156), whereas a higher intake of PUFA (OR, 0.25; P … trend = 0.006) and MUFA (OR, 0.24; P for trend < 0.0001) presented an inverse association.”

“RESULTS While saturated fatty acid (SFA) and n-6 polyunsaturated fatty acid (PU A) l evels decreased significantly during the intervention, monounsaturated fatty acid (MUF A) a nd n-3 PUFA showed the opposite trend.”

“ MUFA proportion was negatively correlated with n-6 PUFA , high density lipoprotein cholesterol (HDL-C), and albumin.”

“In men, pork and beef; squid, octopus, shrimp, and … and protein, animal protein, fat, animal fat, carbohydrate, monounsaturated fatty acid, polyunsaturated fatty acid (PUFA), n-3 PUFA, n-6 PUFA, cholesterol, vitamin D, vitamin B2, vitamin …-reported PS levels and drinking status (p for interaction <0.05 for all).”