Possible Interaction: Fatty Acids, Monounsaturated and Palmitic Acid

“Accumulated studies demonstrate that saturated fatty acids (FAs) such as palmitic acid (PA) inhibit insulin signaling in skeletal muscle cells and monounsaturated fatty acids such as oleic acid (OA) reverse the effect of PA on insulin signaling.”

“Finally, each monounsaturated fatty acid improved beta-cell secretory function that was reduced by palmitic acid and by high glucose.”

“Moreover, each monounsaturated fatty acid prevented the deleterious effects of both palmitic acid and high glucose concentration.”

“Thus, in human islets, the saturated palmitic acid and elevated glucose concentration induce beta-cell apoptosis, decrease beta-cell proliferation, and impair beta-cell function, which can be prevented by monounsaturated fatty acids.”

“Simultaneously, a decrease in monounsaturated fatty acids and increase in palmitic acid are observed.”