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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Fatty Acids, Monounsaturated
drug:
Palmitate
Research Papers that Mention the Interaction
“The effects of palmitate on NRG-1beta signaling and survival were reversed by the mono-unsaturated fatty acid oleate.”
Palmitate alters neuregulin signaling and biology in cardiac myocytes.“We also observed that monounsaturated fatty acids like palmitoleate and oleate mitigates placental trophoblast lipoapoptosis caused due to PA exposure.”
“In conclusion, monounsaturated fatty acids confer protection against the cytotoxic effects of palmitate in vascular endothelial cells; and palmitate-mediated damage, as well as monounsaturated-mediated protection, are due in part to inactivation and activation, respectively, of the metabolic regulator AMPK.”
“The monounsaturated fatty acids oleate and palmitoleate completely prevented the cytotoxic effects of palmitate.”
“These changes were not evident in myotubes incubated … PO, OL or LO alone, and, strikingly, these MUFAs and PUFA not only … the proinflammatory action of PA , but antagonised the biochemical, morphological and functional changes in mitochondrial biology and ROS production induced in myotubes by the sustained oversupply of PA.”
Mono- and Polyunsaturated Fatty Acids Counter Palmitate-Induced Mitochondrial Dysfunction in Rat Skeletal Muscle Cells.“ Palmitate treatment suppressed the percentage of B cells activated through lipoapoptosis, which was differentially prevented by cosupplementing cells with MUFAs and PUFAs.”
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