Possible Interaction: Factor Ix and Tretinoin

“Genes showing negative correlation underlined FGF and retinoic acid signaling as critical canonical pathways disrupted by DNA methylation in PTC.”

“ RA increased GATA4 transcripts by 12- +/- 1-fold in F9 WT at 48 hours, but not in F9 RARgamma-/- cells.”

“Since RA significantly increased the level of p27 protein (approximately 24-fold) in F9 Wt as compared to the F9 RARbeta(2)(-/-) cells, we chose to study p27 in greater detail.”

“Retinoic acid RA ) induces the differentiation of many murine teratocarcinoma cell lines such as F9 and P19.”

“We show by Northern hybridization and metabolic …‐proline followed by SDS‐gel electrophoresis that retinoic acid at 3 … II, IX , and X collagen gene expression within 2 days both at the mRNA and protein level … the onset of α1(I), α2(I), and α1(III) expression within 3 days.”

“In the embryonal carcinoma cell line F9 considerable constitutive levels of hsp25 were observed which could be slightly increased by treatment with retinoic acid.”

“Addition of retinoic acid to F9 cell medium caused a dose-dependent increase in RAR-beta mRNA within 3 hr that reached 5- to 30-fold greater than the constitutively expressed mRNA by 24 hr.”

“ Retinoid … F9 and PCC4 cells caused an increase in cAMP-PK activity as measured by histone phosphorylation, as well as increases in the amount of the … of the cAMP-PKs, as quantitated by photoaffinity labeling with 8-azido-cyclic-32P-AMP, in both the soluble and plasma-membrane fractions.”

“The mouse teratocarcinoma stem cell line, F9 , becomes permissive for productive polyoma infection upon treatment with retinoic acid.”