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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Factor Ix and Magnesium Cation

Research Papers that Mention the Interaction

During the sustained phase of coagulation, FIX is activated by factor XIa (FXIa) requiring Ca2+ [1], and Mg2+ is thought to potentiate the rate of this reaction [5].
In the presence of Mg2+ , numbers of Ca2+ binding sites in FIX were reduced to ~7.1 (Fig. 1A) at saturating Ca2+ concentrations, and to ~5.8 at 1.1 mM physiologic Ca2+ concentration [6], respectively.
Journal of thrombosis and haemostasis : JTH  •  2009  |  View Paper