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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Factor Ix
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“These drugs … range) some CA isozymes involved in critical physiologic processes, among the 16 present in … against CA VII, XII, and XIII, chlorthalidone against CA VB, VII, IX , XII, and XIII, indapamide against CA VII, IX, XII, and XIII, …, II, and XIV, and bumetanide against CA IX and XII.”
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.“Both Sr 2+ and Mn 2+ effectively displace Ca 2+ from human Factor IX ; whereas Mg 2+ is considerably less potent in this regard.”
“Conversely, Ca 2 + is capable of nearly complete displacement of Sr 2+ from its binding sites on human Factor IX.”
“The activation of human Factor IX , by human Factor XIa, shows a complex dependence on the Ca 2 + concentration.”
“The interaction of Ca with human factor IX.”
“The three-dimensional structure of the Gla domain of FIX in the presence of calcium indicates that the acylation of the amino-terminus, rather than the presence of the propeptide, was responsible for the destabilization of the calcium-induced conformation.”
“In the presence of Ca2+, Factor IX Gla domain peptides that contain the photoactivatable amino acid p-benzoyl-L-phenylalanine at positions 6 or 9 cross-link to phospholipid following irradiation, while peptides lacking this amino acid analog or with this analog at position 46 did not cross-link.”
“The absence of coagulant activity in Factor IX San Dimas can be attributed to impaired calcium-induced conformational changes and loss in the ability to bind phospholipid vesicles in the presence of calcium ions.”
“ Factor IX is activated in the presence of calcium by activated factor XI (activation product), a reaction which is accelerated by thrombin.”
“The following metal ions, at concentrations which … metal ions, i.e., Ba 2+ , and Mg 2+ , … factor IX of 25%, compared to Ca 2+ , The lanthanides, Gd 2+ , and Tb 3+ , also promoted activation … the esterase activity of bovine factor IXa was dependent upon the presence of metal ions.”
The influence of metal ions in the activation of bovine factor IX by the coagulant protein of Russell's viper venom.“In the presence of calcium ions , both the precursor and activated form of factor IX showed reduction in sizes.”
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