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Last Updated: 2 months ago

Possible Interaction: Eugenol and Glutathione

drug:

Eugenol

supplement:

Glutathione

Research Papers that Mention the Interaction

At concentrations of 3 mmol/L and 4 mmol/L, eugenol depleted about 45% and 77% of GSH after one-hour incubation.
Journal of dental research  •  1994  |  View Paper
Exposure of human HepG2 hepatoma cells to eugenol depleted the level of intracellular glutathione.
Intracellular glutathione levels were, apparently, significant in mediating the toxicity of eugenol.
Toxicology in vitro : an international journal published in association with BIBRA  •  1993  |  View Paper
EU treatment caused enhanced activities of enzymic antioxidants and diminished both GSH and total thiols.
Further EU enhanced the reduced glutathione ( GSH ) levels and also ameliorated the levels of 3 - nitrotyrosine and expression of HSP70.
Neurochemistry International  •  2016  |  View Paper
Coadministration of glutathione ethyl ester enhanced intracellular GSH levels by almost 100% and completely protected cells from cell death caused by eugenol and EQM.
Eugenol depleted intracellular GSH , inhibited GJIC and generation of ROS, and had a modest effect on MMP at concentrations of 10 to 100 microM. At high concentrations (1000 microM), eugenol also affected [Ca2+]i, PMP, and pH. Effects of EQM were seen at lower concentrations (1 to 10 microM).
Toxicology and applied pharmacology  •  1998  |  View Paper
Concentrations of 1 mM eugenol caused a loss of over 90% of intracellular glutathione and resulted in approximately 85% cell death over a 5-h incubation period.
Chemico-biological interactions  •  1991  |  View Paper
These results suggested that glutathione reacted with the eugenol phenoxyl radical and reduced it back to the parent compound.
The Journal of biological chemistry  •  1989  |  View Paper