Possible Interaction: Etretinate and Selenium

“Although some researchers have been unable to demonstrate any protective effect of different synthetic retinoids against 1,2-dimethylhydrazine or N-methyl-N-nitrosourea-… that the process of tumor initiation in colon mucosa can be significantly influenced by the aromatic retinoid Tigason or by simultaneous administration of Tigason … selenium.”

“In comparison to the 1,2-dimethylhydrazinetreated group, administration of Tigason or Tigason plus selenium reduced tumor incidence (71% and 68%, respectively).”