Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Etorphine and Yohimbine



Research Papers that Mention the Interaction

Yohimbine did not suppress the inhibitory effect of etorphine on protein output but showed some antagonism against the effects of etorphine on water and bicarbonate output.
European journal of pharmacology  •  1986  |  View Paper
Conversely, systemic yohimbine (1 mg/kg) attenuated the effects of central etorphine , and diminished potentiation of etorphine by the alpha 2 agonists.
Prior microinjection of clonidine (5 micrograms) or guanfacine (5 micrograms) into the locus coeruleus (LC) reduced the intensity of central etorphine antinociception whereas central yohimbine (20 micrograms) pretreatment increased peak antinociceptive activity and prolonged the duration of etorphine.
Brain research  •  1984  |  View Paper