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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Etoposide
supplement:
Tocophersolan
Research Papers that Mention the Interaction
“While PEG-400 resulted in the same solubility-permeability tradeoff also in-vivo, TPGS showed the opposite trend: the in-vivo permeability of etoposide was markedly increased in the presence of TPGS.”
Adequate Formulation Approach for Oral Chemotherapy: Etoposide Solubility, Permeability, and Overall Bioavailability from Cosolvent- vs. Vitamin E TPGS-Based Delivery Systems.“ Etoposide in‐vitro PAMPA permeability decreased markedly with increasing TPGS levels, similarly to the solubility‐permeability tradeoff previously defined for surfactants.”
“In contrast, the presence of TPGS significantly increased etoposide in‐vivo rat permeability, attributable to P‐gp inhibition, similarly to the effect of the potent P‐gp inhibitor GF120918 (10 &mgr;g/mL).”
“ TPGS above CMC (0.3 mg/mL) increased etoposide solubility linearly, and ASD allowed significant supersaturation.”
“It was found that ETO-loaded TPGS-LA NPs were noticeably able to enhance the cytotoxicity of ETO in HepG2 cells.”
Lactobionic acid-conjugated TPGS nanoparticles for enhancing therapeutic efficacy of etoposide against hepatocellular carcinoma.“The absorptive … of etoposide was significantly enhanced (p < 0.001) in … presence of verapamil (100 μg/mL) and TPGS (over the concentration range of 0.002- 0.1 mg/mL), suggesting that the inhibition … P-gp located in the intestine may be involved in the enhancement of etoposide absorption.”
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