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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Etoposide
supplement:
Resveratrol
Research Papers that Mention the Interaction
“These findings suggested that down‐regulation of XRCC1 expression by resveratrol can enhance the chemosensitivity of etoposide in NSCLC cells.”
Resveratrol Enhances Etoposide‐Induced Cytotoxicity through Down‐Regulating ERK1/2 and AKT‐Mediated X‐ray Repair Cross‐Complement Group 1 (XRCC1) Protein Expression in Human Non‐Small‐Cell Lung Cancer Cells“Abstract Conclusion: Resveratrol shows a growth inhibitory effect in head and neck squamous cell carcinoma (HNSCC) cell lines and acts synergistically in combination with etoposide in three cell lines via the induction of apoptotic and necrotic cell death.”
“The aim of this study was to investigate whether resveratrol is able to enhance the antiproliferative effect of etoposide in vitro synergistically.”
“Interestingly in HepG2 cells, resveratrol exhibited the same levels of cytotoxicity as etoposide (10 μM) when the cells treated with ≥ 25 μM for 48-72 h. In contrast to HepG2, resveratrol significantly enhanced anti-proliferative effects of etoposide in HCT-116 cells.”
“The ability of resveratrol to enhance anti-proliferative effects of etoposide in wild type p53 liver carcinoma (HepG2) and colon cancer (HCT-116) cells was investigated with focusing on p53 activation.”
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