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Last Updated: 2 months ago

Possible Interaction: Etoposide and Quinidine

supplement:

Quinidine

Research Papers that Mention the Interaction

That is, morphine and quinidine significantly increased the bioavailability of etoposide believed to be due to competitive P-gp inhibition in the intestine.
Biological & pharmaceutical bulletin  •  2014  |  View Paper
Adding quinidine at 1 mg/ml to the everted gut sac increased the absorption of etoposide.
Intravenous infusion of quinidine at either 1 or 2 mg/h increased the serum level of etoposide in a dose-dependent manner.
The present data confirm that intestinal Pgp mediates the efflux of etoposide and that the use of Pgp-inhibiting agents such as quinidine may increase the bioavailability of etoposide.
Cancer Chemotherapy and Pharmacology  •  2009  |  View Paper
In the presence of inhibitors such as 2,4-dinitrophenol (1 mM) and quinidine (1 mM), etoposide showed an increase in Jm–s and a decrease in Js–m.
Pharmaceutical Research  •  2005  |  View Paper
There was a statistically significant (p < 0.05) increase in serum BSP levels with CYP3A and P-gp substrates and/or inhibitors, cyclosporine-A, nitrendipine, quinidine , indinavir, daxorubicin, etoposide and erythromycin by 27%, 35%, 32%, 12%, 5%, 22%, and 106%, respectively.
Die Pharmazie  •  2004  |  View Paper
The results showed that the transport of etoposide was significantly increased from the luminal site to the serosal site in the jejunum by 2- and 4-fold after 90 min in the presence of hydroxyzine and quinidine , respectively.
Anti-cancer drugs  •  2001  |  View Paper