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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Etoposide and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

In conclusion, ETP treatment appears to up-regulate PtdIns(4,5)P2 expression via RhoA/ROCK signaling, leading to the activation of ERM, presumably through the physical interaction of radixin with PtdIns(4,5)P2.
Repeated oral treatment with ETP (10 mg/kg/d) over 5 d significantly increased PtdIns(4,5)P2 expression in the ileal membrane as measured by dot blot.
Biological & pharmaceutical bulletin  •  2014  |  View Paper
PtdIns(4,5)P2 and PI4P5K may contribute to the increase in ileal P-gp expression observed following the ETP treatment, possibly through ERM activation via the RhoA/ROCK pathway.
Journal of pharmaceutical sciences  •  2014  |  View Paper