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Last Updated: 2 months ago

Possible Interaction: Etoposide and Melatonin

supplement:

Melatonin

Research Papers that Mention the Interaction

SummaryA significant myeloprotective effect of melatonin in mice treated with etoposide , cyclophosphamide or carboplatin has been reported.
British Journal of Cancer  •  1999  |  View Paper
Melatonin reduced the effects of etoposide significantly in both types of experiment conditions, through the reduction of the level of DNA damage measured via comet assay.
The most protective effect was observed with melatonin when it was administrated 24 h before etoposide treatment.
Pharmacology  •  2018  |  View Paper
In addition to cytokines such as hrTNF-alpha and TRAIL, chemotherapeutic compounds, including doxorubicin, docetaxel, or etoposide , were employed in combination with melatonin to promote cell death.
Journal of pineal research  •  2013  |  View Paper
Animal models further demonstrated that a combination of melatonin and the chemotherapeutic agent etoposide (VP16) can significantly enhance tumor growth inhibition compared with monotherapy.
Cancers  •  2018  |  View Paper
In vitro, melatonin proved to counteract apoptosis in bone marrow cells incubated with etoposide.
Cancer research  •  1994  |  View Paper