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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Etoposide
supplement:
Glutathione
Research Papers that Mention the Interaction
“However, treatment with etoposide or vincristine (at similar molar concentrations) caused a 20% decrease in glutathione.”
Verapamil-stimulated glutathione transport by the multidrug resistance-associated protein (MRP1) in leukaemia cells.“Vanadate-induced nucleotide trapping in MRP1 was found to be stimulated by reduced glutathione, glutathione disulfide, and etoposide and to be synergistically stimulated by the presence of etoposide and either glutathione.”
“These results suggest that GSH plays a role in the enhancement of MRP-mediated glucuronosyl etoposide transport.”
“Transport of glucuronosyl etoposide was augmented in the presence of GSH.”
“The export of GSH from wild-type ES cells, but not from the MRP double knockout clones, increased in the presence of etoposide (VP-16) and sodium arsenite, accompanied by equivalent decreases in intracellular levels of GSH.”
Evidence that the multidrug resistance protein (MRP) functions as a co-transporter of glutathione and natural product toxins.
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