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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Additional experiments in 4 cases showed that herbimycin A had no effect on DNA synthesis rate while etoposide inhibited similarly to that of genistein.”
Rapid inhibition of ongoing DNA synthesis in human glioma tissue by genistein.“Combinations of genistein or tyrphostin AG 1478 with cisplatin, doxorubicin, or etoposide enhanced the antiproliferative effects and induced programmed cell death in NCI-H596 cells, whereas no such additive effects were observed in NCI-H358 cells.”
“ etoposide and ACNU was significantly lower in K562/TPA than in K562, but was significantly increased in the presence of genistein.”
“ Genistein decreased the … poison etoposide , suggestive of a catalytic inhibition of topo II, and luteolin decreased the topo I-DNA complexes induced by the topo I poison … I. Murine transgenic cells lacking topo II beta were resistant to genistein-induced cell growth inhibition (XTT assays) and cytotoxicity (clonogenic assay).”
Cells lacking DNA topoisomerase II beta are resistant to genistein.“While the inclusion of etoposide in nonturnover DNA catenation assays reversed the inhibition of strand passage induced by genistein , CP-115,953, and amsacrine, it had no effect on the inhibition induced by novobiocin.”
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