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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Etomidate and Serine

supplement:

Serine

Research Papers that Mention the Interaction

Mechanistic analyses suggest that substitution with serine , the β1 residue at this position, primarily reduces etomidate efficacy, while mutation to methionine eliminates etomidate sensitivity and might prevent drug binding.
PloS one  •  2014  |  View Paper
The mutation of an amino acid (Asn-289) present within the channel domain of the beta3 subunit to Ser (the homologous residue in beta1), strongly suppressed the GABA-modulatory and GABA-mimetic effects of etomidate.
Proceedings of the National Academy of Sciences of the United States of America  •  1997  |  View Paper