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Last Updated: 2 months ago

Possible Interaction: Etomidate and Adrenocorticotropic Hormone

Research Papers that Mention the Interaction

ACTH and beta-endorphin levels increased in patients receiving etomidate , presumably as a result of the interruption of negative feedback due to cortisol synthesis inhibition.
The cortisol decrease from 12.5 +/- 1.7 to 7.6 +/- 1.5 caused by midazolam was similar to that following etomidate, but the response to exogenous ACTH was significantly impaired in patients receiving etomidate as compared to those receiving midazolam.
Anesthesiology  •  1987  |  View Paper
Etomidate-exposed patients treated with hydrocortisone had fewer ventilator days (p < 0.001).ConclusionsAmong the patients enrolled in the study, etomidate did not alter basal cortisolemia, but it did decrease reactivity to corticotropin.
There was a correlation between time from etomidate injection to inclusion in the study and sensitivity to corticotropin (R2 = 0.19; p = 0.001).
Intensive Care Medicine  •  2012  |  View Paper
Although cortisol increases with exogenous ACTH, levels were lower in sepsis than in nonsepsis patients, and etomidate was associated with diminished increases in cortisol with exogenous ACTH , so that its use increased, albeit nonsignificantly, low cortisol increases to exogenous ACTH from 38% to 57%, in both conditions.
Critical Care  •  2012  |  View Paper
In a septic shock population, we tested the hypotheses that etomidate administration induces more non-responders to corticotropin and increases mortality and that hydrocortisone treatment decreases mortality in patients receiving etomidate.
The proportion of non-responders to corticotropin was significantly higher in patients who were given etomidate in the 72 h before trial inclusion than in other patients (61.0 vs. 44.6%, P = 0.004).
Intensive Care Medicine  •  2009  |  View Paper
Etomidate influenced ACTH test results and was associated with a worse outcome.
Critical care medicine  •  2007  |  View Paper
In the group of patients who received etomidate (n = 10), cortisol and aldosterone responses to adrenocorticotrophic hormone were blunted, while 11-de-oxycortisol response was increased, as compared to a control group (n = 10).
Anaesthesia  •  1988  |  View Paper
Median plasma cortisol concentrations measured at 0900 were significantly lower and median plasma concentrations of adrenocorticotrophic hormone measured at 0900 were significantly higher in the three patients studied prospectively who were receiving etomidate infusions compared with the three patients who did not receive etomidate (p = 0.05).
British medical journal  •  1983  |  View Paper
During the infusion of etomidate , a significant increase in the peripheral concentration of ACTH occurred, while plasma cortisol concentrations decreased.
The Journal of clinical endocrinology and metabolism  •  1984  |  View Paper
Four surgical patients receiving etomidate during their operations were all found to have adrenal suppression four hours after the operation; mean (+/- S.D.) increases in cortisol and aldosterone after ACTH stimulation were only 1.8 +/- 0.5 micrograms per deciliter and 0.5 +/- 1.1 ng per deciliter, respectively.
The New England journal of medicine  •  1984  |  View Paper