Possible Interaction: Etidronate and Calcium Supplement

“The ultrafiltrability of HEBP and PPi, but not of Cl2MBP was reduced by 1 mM Ca and 5 mM Pi at a 50'000 dalton cut-off.”

“ EHDP slightly increased the calcium concentration in the released cells and slightly decreased the rate constant of the calcium transport, having opposite effects when it was inside or outside the cells.”

“Histological studies during the early phase of treatment indicated that etidronate , but not clodronate or AHDP, acutely impaired the accretion of calcium into bone, thereby offsetting a hypocalcaemic response.”

“After 2 weeks of administration in the heart, 0.006 and 0.03% (w/v) HEBP decreased calcium content by 90 and 30%, respectively, while 0.27 and 2.7 mg/ml Dai-saiko-to reduced calcium content by 30 and 45%, respectively.”

“In the tongue, at 4 weeks, 0.006 and 0.03% (w/v) HEBP reduced calcium content by 30 and 45%, respectively, while two Kampo medicines (at both concentrations used) significantly reduced the content of calcium (by 27-79%) and phosphorus (by 24-32%).”

“ EHDP reduced the frequency of renal stone and calcium content in the kidney, and reduced the size of the stones in the renal pelvis and ureter.”

“ EHDP suppressed urinary excretion of calcium even though serum calcium slightly increased.”

“An equivalent dose of HEBP caused substantial changes in osseous tissues and calcium parameters.”

“The prevention of excessive deposition of arterial calcium by EHDP and also by Colcemid may play an important role in the antiatherogenic effect of these drugs.”