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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ethylketocyclazocine
supplement:
Yohimbine
Research Papers that Mention the Interaction
“Inhibition of stimulation-evoked NA release by the preferential kappa-receptor agonist ethylketocyclazocine EKC ) was increased in the presence of the alpha 2-adrenoceptor antagonist yohimbine (0.1 or 1.0 microM).”
Presynaptic kappa-opioid receptors on noradrenergic nerve terminals couple to G proteins and interact with the alpha 2-adrenoceptors.“The selective kappa-receptor agonist ethylketocyclazocine EK ) attenuated markedly the release-inhibiting effects of the alpha 2-adrenoceptor-selective agonists clonidine and alpha-methylnoradrenaline as well as the release-facilitating effect of the alpha 2-adrenoceptor-selective antagonist yohimbine.”
“ Ethylketocyclazocine also depressed the evoked overflow of tritium when yohimbine was present.”
“The inhibition produced by ethylketocyclazocine in the presence of yohimbine was antagonized by (-)-3-furylmethyl)-alpha-noretazocine (MR 2266) but not by N,N-diallyl-Tyr-alpha-aminoisobutyric acid-alpha-aminoisobutyric acid-Phe-Leu-OH (ICI 174864).”
“When yohimbine was administered first and kept for the rest of the experiment, the effect of EK was enhanced.”
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