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Last Updated: 3 months ago

Possible Interaction: Ethylketocyclazocine and Yohimbine

Research Papers that Mention the Interaction

Inhibition of stimulation-evoked NA release by the preferential kappa-receptor agonist ethylketocyclazocine EKC ) was increased in the presence of the alpha 2-adrenoceptor antagonist yohimbine (0.1 or 1.0 microM).
Journal of neurochemistry  •  1989  |  View Paper
The selective kappa-receptor agonist ethylketocyclazocine EK ) attenuated markedly the release-inhibiting effects of the alpha 2-adrenoceptor-selective agonists clonidine and alpha-methylnoradrenaline as well as the release-facilitating effect of the alpha 2-adrenoceptor-selective antagonist yohimbine.
Naunyn-Schmiedeberg's archives of pharmacology  •  1988  |  View Paper
Ethylketocyclazocine also depressed the evoked overflow of tritium when yohimbine was present.
The inhibition produced by ethylketocyclazocine in the presence of yohimbine was antagonized by (-)-3-furylmethyl)-alpha-noretazocine (MR 2266) but not by N,N-diallyl-Tyr-alpha-aminoisobutyric acid-alpha-aminoisobutyric acid-Phe-Leu-OH (ICI 174864).
Naunyn-Schmiedeberg's archives of pharmacology  •  1986  |  View Paper
When yohimbine was administered first and kept for the rest of the experiment, the effect of EK was enhanced.
Naunyn-Schmiedeberg's archives of pharmacology  •  1986  |  View Paper