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Last Updated: 2 years ago

Possible Interaction: Ethosuximide and Gamma-Aminobutyric Acid

Research Papers that Mention the Interaction

3 ES , in high concentrations (1–10 mm), reduced GABA responses to a lesser extent, and also occluded the reductions in GABA‐evoked currents produced by TMS, picrotoxin, and PTZ.
British journal of pharmacology  •  1990  |  View Paper
The administration of 500 mg/kg/day of ethosuximide for 1, 2, 4, 6, 8 and 11 days induced neurotoxicity in 100, 100, 67, 0, 0 and 0% of animals, respectively, and increased brain GABA concentration 46, 38, 25, 14, 9 and 0%, respectively.
These results indicate that the antipentylenetetrazol activity of ethosuximide is unrelated to GABA function and that the increase in brain GABA concentration induced by toxic doses of ethosuximide contributes to its neurotoxicity.
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper