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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Ethinyl Estradiol and Vitamin C

Research Papers that Mention the Interaction

Ascorbic acid can, therefore, be removed from the list of drugs interfering with the pharmacokinetics of ethinyl estradiol.
Previous studies in small numbers of women have suggested that the administration of gram quantities of ascorbic acid interferes with the conversion of ethinyl estradiol (EE2) to its sulfates, leading to higher blood levels of EE2.
Contraception  •  1993  |  View Paper
Plasma concentrations of ethinylestradiol may be increased by ascorbic acid (vitamin C) and paracetamol (acetaminophen) which compete with it for sulphation in the gut wall.
Drug safety  •  1993  |  View Paper
Plasma ethinylestradiol increases 47.6% when taken with ascorbic acid because of competition in producing sulfate conjugation.
  •  1992  |  View Paper
Ascorbic acid has recently been found to enhance the effect of OCs: the plasma concentration of EE is significantly higher in OC users taking 1 g of ascorbic acid than in the same subjects taking the OC alone.
Ascorbic acid has recently been found to enhance the effect of OCs: the plasma concentration of EE is significantly higher in OC users taking 1 g of ascorbic acid than in the same subjects taking the OC alone.
IPPF medical bulletin  •  1983  |  View Paper
Two drugs, ascorbic acid (vitamin C) and paracetamol (acetaminophen), give rise to increased blood concentrations of ethinylestradiol due to competition for sulphation.
Clinical pharmacokinetics  •  1990  |  View Paper
In vitro studies revealed a markedly higher rate of oxidation of ascorbic acid in the presence of either estinyl or progestogen than in untreated controls.
Oral … either estinyl (5 micrograms) or progestogen (250 … combination with 5 mg of ascorbic acid (minimum requirement) daily for 21 d, resulted in significantly lower (P less than 0.05) concentrations of … acid in plasma, liver, adrenals and urine than in animals receiving only 5 mg of the vitamin.
The Journal of nutrition  •  1986  |  View Paper
These results confirm previous data showing in humans the capability of ascorbic acid to favour the rise of plasma concentrations of ethynylestradiol.
Methods and findings in experimental and clinical pharmacology  •  1982  |  View Paper