Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Ethinyl Estradiol and Progestins

Research Papers that Mention the Interaction

Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol (EE) is associated with increased risk of venous thromboembolism.
Thrombosis and haemostasis  •  2011  |  View Paper
BACKGROUND Ethinyl estradiol (EE) increases endothelium-dependent vasodilation in young women, but certain progestins paired with EE in combination oral contraceptive pills (OCPs) have been shown to antagonize the vasodilatory effects of EE.
Contraception  •  2010  |  View Paper
It is therefore possible that both steroids decreased the hepatic output of triglycerides, which may be clinically important since both progestins are used in combination with ethinylestradiol (EE) which increases the hepatic TG synthesis.
Atherosclerosis  •  1985  |  View Paper
Treatment with estrogens (specifically oral ethinylestradiol ) of transgender women, particularly in combination with progestins , carries a significant relative risk of developing cardiovascular disease (almost a twofold incidence compared to the general population).
Reviews in Endocrine and Metabolic Disorders  •  2018  |  View Paper
Compared with progestogens with androgenic properties which may restrict the stimulatory action of ethinylestradiol on haemostatic parameters, the newer progestogens do not seem to be superior with respect to haemostasis.
Drugs  •  2012  |  View Paper
Combined use of EE and synthetic progestogens may therefore enhance estrogen effects on body sodium and blood pressure.
Steroids  •  1996  |  View Paper
Studies suggest an association between combinations of EE and progestogens and ischaemic stroke, which in particular concerns women with migraine.
BMJ Sexual & Reproductive Health  •  2020  |  View Paper
RESULTS Women using … of et inyl estradiol + p gestogen ha d significantly lower mean ASM (18.0), RSMI (6.5), TLM (40.8) (p < 0.01) and GS (34.6) (p < 0.… not using hormonal contraception with mean values of ASM (18.8), RSMI (6.7), TLM (42.6) and GS (36.9).
European journal of obstetrics, gynecology, and reproductive biology  •  2019  |  View Paper
In the case of the other five reductases, gestagens had remarkably stronger inhibitory effects at a concentration of 25 μM (progesterone: 66-88% inhibition; drospirenone: 26-87% inhibition) in comparison to estrogens (estradiol: 17-51% inhibition; ethinylestradiol : 14-79% inhibition) and androgens (14-78% inhibition).
Chemico-biological interactions  •  2017  |  View Paper
In recent years, there has been an important and intensive controversy regarding the thromboembolic risk of hormonal contraceptives containing ethinylestradiol combined with certain progestogens like desogestrel, drospirenone and cyproterone acetate.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception  •  2017  |  View Paper
Show More