Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 months ago

Possible Interaction: Ethinyl Estradiol and Progestins

Research Papers that Mention the Interaction

Use of oral contraceptives (OC) that combine a progestogen with synthetic ethinyl estradiol ( EE ) is associated with increased risk of venous thromboembolism.
Thrombosis and haemostasis  •  2011  |  View Paper
BACKGROUND Ethinyl estradiol (EE) increases endothelium-dependent vasodilation in young women, but certain progestins paired with EE in combination oral contraceptive pills (OCPs) have been shown to antagonize the vasodilatory effects of EE.
Contraception  •  2010  |  View Paper
Conversely, both progestins suppressed sex hormone binding globulin levels, but addition of ethinyloestradiol caused marked increases above baseline.
Hepatic lipase was activated with either progestin when administered alone but its activity was suppressed below the baseline level when ethinyloestradiol was added.
Clinical endocrinology  •  1992  |  View Paper
It is therefore possible that both steroids decreased the hepatic output of triglycerides, which may be clinically important since both progestins are used in combination with ethinylestradiol (EE) which increases the hepatic TG synthesis.
Atherosclerosis  •  1985  |  View Paper
RESULTS … combination of ethinyl estradiol + progestogen had significantly lower mean ASM (18.0), RSMI (6.5), TLM (40.8) (p < 0.01) and GS (34.6) (p < 0.… not using hormonal contraception with mean values of ASM (18.8), RSMI (6.7), TLM (42.6) and GS (36.9).
European journal of obstetrics, gynecology, and reproductive biology  •  2019  |  View Paper
Ethinyl estradiol and progestogen , contained within combined hormonal contraception, are known to impact lipid metabolism.
Contraception  •  2016  |  View Paper
The effect size depended both on the progestogen used and the dose of ethinylestradiol.
The Cochrane database of systematic reviews  •  2014  |  View Paper
The effect size depended both on the progestogen used and the dose of ethinylestradiol.
BMJ : British Medical Journal  •  2013  |  View Paper
Because the pharmacologic androgenicity of the progestin in these formulations influences the hepatic impact of EE , we selected an oral contraceptive (OC) delivering the androgenic progestin levonorgestrel (LNG) and EE as the comparator.
Contraception  •  2007  |  View Paper
All combined contraceptives progestin plus ethynyl estradiol ) produced some deterioration of glucose in the tolerance tests and increase in insulin secretion, although these changes were within normal accepted levels.
Ginecologia y obstetricia de Mexico  •  1996  |  View Paper
Show More