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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Ethinyl Estradiol
supplement:
Progesterone
Research Papers that Mention the Interaction
“The drug-binding site (or receptor) for progesterone probably interacts allosterically with the binding site for ethinyloestradiol and thereby decreasing its transport enhancing effects on chlorpromazine.”
Effect of oral contraceptives on the transport of chlorpromazine across the CACO-2 intestinal epithelial cell line.“The ACTH-stimulated concentration of progesterone and of 17alpha-hydroxyprogesterone were significantly reduced during intake of ethinyl estradiol.”
“Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL … 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 … priming with ethinyl estradiol resulted in a surge-like release … and FSH in all subjects.”
“Compared to the respective vehicle-treated control groups, EE decreased cerebral cortical levels of allopregnanolone, progesterone and pregnenolone by 76, 72 and 33%, respectively and hippocampal levels by 52, 56 and 50%, respectively.”
Long-term administration with levonorgestrel decreases allopregnanolone levels and alters GABAA receptor subunit expression and anxiety-like behavior“However, in the presence of 20 nM EE , the binding affinity of radiolabeled progesterone to receptor was inhibited (increase in Kd from 0.98 nM in controls to 3.02 nM in the presence of EE).”
“However, in the uterus of ethinylestradiol-primed rats, a partial decrease of total and occupied nuclear E2R accumulation was observed in the presence of the three doses of progesterone used.”
“Studies in adipose tissue showed that treatment with ethynyl estradiol and progesterone , separately or in combination, increased lipoprotein lipase activit...”
“The combined regimen of ethynyl e$tradiol plus progesterone caused maximal decreases in hepatic lipases, a 29% decrease in the triglyceride content of liver, but no change in the level of triglycerides in blood.”
“When the concentration of progesterone exceeded that of the inhibiting hormone E activated and EE inhibited enzyme activity.”
“The solubilizations of ethinyl estradiol and the two C21 steroids, progesterone and 21-hydroxyprogesterone, were dependent on each other so that a varying amount of the steroid solubilized first was precipitated by an excess of the second steroid.”
Simultaneous solubilization of steroid hormones I: estrogens and C21 steroids.
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