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Last Updated: 3 years ago

Possible Interaction: Ethinyl Estradiol and Progesterone

Research Papers that Mention the Interaction

The drug-binding site (or receptor) for progesterone probably interacts allosterically with the binding site for ethinyloestradiol and thereby decreasing its transport enhancing effects on chlorpromazine.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V  •  2003  |  View Paper
The ACTH-stimulated concentration of progesterone and of 17alpha-hydroxyprogesterone were significantly reduced during intake of ethinyl estradiol.
Human reproduction  •  2002  |  View Paper
Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL … 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 … priming with ethinyl estradiol resulted in a surge-like release … and FSH in all subjects.
The Journal of clinical endocrinology and metabolism  •  1992  |  View Paper
Compared to the respective vehicle-treated control groups, EE decreased cerebral cortical levels of allopregnanolone, progesterone and pregnenolone by 76, 72 and 33%, respectively and hippocampal levels by 52, 56 and 50%, respectively.
Pharmacology Biochemistry and Behavior  •  2012  |  View Paper
However, in the presence of 20 nM EE , the binding affinity of radiolabeled progesterone to receptor was inhibited (increase in Kd from 0.98 nM in controls to 3.02 nM in the presence of EE).
Endocrinology  •  1993  |  View Paper
However, in the uterus of ethinylestradiol-primed rats, a partial decrease of total and occupied nuclear E2R accumulation was observed in the presence of the three doses of progesterone used.
The Journal of Steroid Biochemistry and Molecular Biology  •  1990  |  View Paper
Studies in adipose tissue showed that treatment with ethynyl estradiol and progesterone , separately or in combination, increased lipoprotein lipase activit...
The combined regimen of ethynyl e$tradiol plus progesterone caused maximal decreases in hepatic lipases, a 29% decrease in the triglyceride content of liver, but no change in the level of triglycerides in blood.
Endocrinology  •  1978  |  View Paper
When the concentration of progesterone exceeded that of the inhibiting hormone E activated and EE inhibited enzyme activity.
Biochemical pharmacology  •  1976  |  View Paper
The solubilizations of ethinyl estradiol and the two C21 steroids, progesterone and 21-hydroxyprogesterone, were dependent on each other so that a varying amount of the steroid solubilized first was precipitated by an excess of the second steroid.
Journal of pharmaceutical sciences  •  1978  |  View Paper